Study: Smokers have powerful mechanisms that protect them from lung cancer

A recent study led by a group of scientists, at Albert Einstein College of Medicine and published online in Nature Genetics, has demonstrated that some smokers may have powerful mechanisms that protect them from lung cancer by limiting mutations.

The study confirmed that for some smokers, the results can help identify those smokers who face an increased risk of contracting the disease, and therefore require careful monitoring in particular.

“This could be an important step toward prevention and early detection of lung cancer risk and away from the risk of developing lung cancer,” said Dr Simon Spivak, co-lead author of the study, professor of medicine, epidemiology, population health, and genetics at Albert Einstein College of Medicine and a pulmonologist at Montefiore Health System. The current massive efforts needed to combat the disease in the late stage.”

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Dr Jan Feig, study co-author and Professor and Chair of the Department of Genetics, and Professor of Ophthalmology and Visual Sciences, in the Department of Molecular Genetics at Albert Einstein College, and also at the Single-celled Omics Center, Jiaotong University School of Medicine in Shanghai, China, was able to overcome This hurdle a few years ago by developing an improved method for whole-genome sequencing of individual cells.

Single-cell whole-genome sequencing methods can introduce sequencing errors that are difficult to distinguish from true mutations—a serious drawback when analyzing cells that contain rare, random mutations.

By Editor

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